Yuan Gu Selected Research

Osteoarthritis

1/2023	HMGB1 can activate cartilage progenitor cells in response to cartilage injury through the CXCL12/CXCR4 pathway.
1/2023	Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through inhibition of prostaglandins.
5/2021	Knockdown of long non-coding RNA KCNQ1OT1 suppresses the progression of osteoarthritis by mediating the miR-211-5p/TCF4 axis in vitro.

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Yuan Gu Research Topics

Disease

31	Neoplasms (Cancer) 04/2024 - 06/2008
9	Infections 01/2020 - 01/2013
9	Trichinellosis 01/2017 - 01/2008
6	Emphysema 05/2012 - 07/2008
5	Breast Neoplasms (Breast Cancer) 01/2023 - 01/2015
4	Inflammation (Inflammations) 03/2024 - 06/2011
4	Neoplasm Metastasis (Metastasis) 06/2023 - 06/2008
4	Carcinogenesis 01/2021 - 09/2009
3	Hypoxia (Hypoxemia) 03/2023 - 03/2022
3	Osteoarthritis 01/2023 - 05/2021
3	Schizophrenia (Dementia Praecox) 01/2022 - 01/2020
2	Bites and Stings (Sting) 03/2024 - 01/2023
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2023 - 02/2016
2	Adenocarcinoma 01/2023 - 08/2019
2	Pain (Aches) 01/2023 - 11/2022
2	COVID-19 01/2022 - 11/2021
2	Chronic Obstructive Pulmonary Disease (COPD) 05/2012 - 09/2009
2	Lung Injury 12/2010 - 07/2008
1	Heart Injuries 03/2024
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 03/2024
1	Obesity 01/2024
1	Pathologic Neovascularization 01/2023
1	Sarcoma (Soft Tissue Sarcoma) 01/2023
1	Heart Failure 01/2023
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023
1	Congenital Heart Defects (Congenital Heart Defect) 01/2023
1	Osteoporosis 01/2023
1	Fibrosarcoma 01/2023
1	Stomach Neoplasms (Stomach Cancer) 01/2023

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2023 - 03/2010
10	VaccinesIBA 01/2018 - 01/2008
7	AntigensIBA 12/2023 - 01/2014
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2012
5	SmokeIBA 05/2012 - 07/2008
4	EpitopesIBA 01/2017 - 01/2013
3	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2023 - 08/2012
3	Estrogen ReceptorsIBA 01/2023 - 01/2018
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023 - 07/2008
3	Complement System Proteins (Complement)IBA 01/2020 - 02/2014
3	TropomyosinIBA 01/2020 - 11/2016
3	CeramidesIBA 12/2010 - 07/2008
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2024 - 08/2023
2	oxidized low density lipoproteinIBA 01/2024 - 01/2020
2	Small Interfering RNA (siRNA)IBA 08/2023 - 05/2021
2	CytokinesIBA 01/2023 - 01/2014
2	Messenger RNA (mRNA)IBA 01/2023 - 12/2015
2	NanovaccinesIBA 01/2023 - 05/2022
2	MicroRNAs (MicroRNA)IBA 01/2023 - 12/2021
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2023 - 02/2010
2	EnzymesIBA 01/2023 - 01/2020
2	BuffersIBA 01/2022 - 11/2021
2	Amino Acids FDA Link 02/2020 - 07/2012
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2020 - 11/2016
2	crocinIBA 11/2019 - 12/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 01/2014
2	Subunit VaccinesIBA 11/2016 - 02/2014
2	A-Form DNA (A-DNA)IBA 01/2016 - 01/2014
2	arctigeninIBA 09/2013 - 08/2012
2	Caspase 3 (Caspase-3)IBA 05/2012 - 09/2009
2	SerpinsIBA 05/2012 - 09/2009
1	ArginaseIBA 04/2024
1	InflammasomesIBA 03/2024
1	Polysaccharides (Glycans)IBA 03/2024
1	Mitochondrial DNA (mtDNA)IBA 03/2024
1	Toll-Like Receptor 7IBA 01/2024
1	low density lipoprotein inhibitorIBA 01/2024
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2024
1	Immune Checkpoint InhibitorsIBA 12/2023
1	Tumor Necrosis Factor Receptor-Associated Peptides and ProteinsIBA 12/2023
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2023
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/2023
1	matrigelIBA 03/2023
1	Hypoxia-Inducible Factor 1IBA 03/2023
1	Protein Kinase C-alphaIBA 03/2023
1	InterferonsIBA 01/2023
1	pro-brain natriuretic peptide (1-76)IBA 01/2023
1	MucinsIBA 01/2023
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2023
1	Phosphotransferases (Kinase)IBA 01/2023
1	Metalloproteases (Metalloproteinases)IBA 01/2023
1	HMGB1 Protein (HMG1)IBA 01/2023
1	ProstaglandinsIBA 01/2023
1	Circular RNAIBA 01/2023
1	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 01/2023
1	Hormones (Hormone)IBA 01/2023
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2023
1	5' Untranslated Regions (5' UTR)IBA 01/2023
1	Matrix Metalloproteinases (MMPs)IBA 01/2023
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2023
1	Mannose (D-Mannose)IBA 01/2023
1	GlucocorticoidsIBA 01/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2023
1	Metformin (Glucophage)FDA LinkGeneric 01/2023

Therapy/Procedure

12	Therapeutics 08/2023 - 06/2011
4	Radiotherapy 12/2023 - 03/2022
2	Radioimmunotherapy 01/2024 - 01/2023
2	Immunotherapy 08/2023 - 05/2022
2	Drug Therapy (Chemotherapy) 01/2023 - 03/2022
1	Aftercare (After-Treatment) 12/2023
1	Photochemotherapy (Photodynamic Therapy) 06/2023